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Biology · cell cross-section

The cella city in miniature

Look inside a cell as if through a fluorescence microscope. There is a city hall with an archive of genes, power plants, protein factories, a post office and walls with gates. Hover over any part or tap it, start the processes of life and watch the cell divide.

Animal cell
10–30 µm
Cells in the body
30–37 trillion
Ribosome
25–30 nm
Lipid membrane
≈ 5 nm
Animal cell · ≈ 20 µm
Colors are arbitrary, like fluorescent dyes. Small structures are enlarged.
Tab organellesEnter zoom in1–3 modes Q quizSpace start/pause←→ stepsEsc back

How does it work?

The cell is the smallest unit of life. Our cells, like those of plants and fungi, are eukaryotic: they have a nucleus and many organelles wrapped in membranes. Each one has its own job, like the districts of a city.

From gene to protein

The recipe for a protein is written in DNA. In the nucleus a gene is copied into mRNA (transcription). The mRNA leaves through a nuclear pore, and a ribosome reads it and links amino acids together (translation). Proteins for export are made on the rough endoplasmic reticulum, get “labels” in the Golgi apparatus and leave the cell in vesicles (exocytosis). More about DNA itself: DNA Helix.

DNA mRNA proteintranscription in the nucleus, translation on the ribosome

Energy: respiration and photosynthesis

Mitochondria “burn” glucose with oxygen and charge up ATP molecules — the cell's universal batteries. Chloroplasts do the reverse: using the energy of light, they build glucose from carbon dioxide and water.

C6H12O6 + 6 O2 ⟶ 6 CO2 + 6 H2O + energy (about 30–32 ATP)cellular respiration (cytosol + mitochondrion)
6 CO2 + 6 H2O + light energy ⟶ C6H12O6 + 6 O2photosynthesis (chloroplast)

A border with checkpoints

The membrane lets small molecules such as O2 and CO2 pass from where they are more concentrated to where they are less concentrated (diffusion). Ions go through protein channels. The sodium-potassium pump uses ATP to move ions “uphill”:

1 ATP ⟶ 3 Na+ out + 2 K+ inactive transport

Why are cells small?

Everything a cell takes in and gets rid of passes through its surface. For a sphere of radius r:

S / V = 4πr2 / (⁴⁄₃ πr3) = 3 / ra cell twice as large has half as much surface per unit of volume

Scale: from a virus to an egg cell

Flu virus≈ 100 nm
Bacterium1–2 µm
Red blood cell≈ 7.5 µm
Typical cell10–30 µm
Egg cell≈ 0.1 mm

Logarithmic scale: the bar spans 10 nm to 1 mm, and each fifth of it is a tenfold increase in size. A human egg cell can be seen with the naked eye as a dot. 1 µm = 0.001 mm, 1 nm = 0.001 µm. More: Scale of the Universe.

What we simplified

This is a flat cross-section, and the organelles are placed at random. Ribosomes, nuclear pores, centrioles and membrane thickness are drawn many times larger so they are visible; the scale bar refers to the whole cell. The colors are arbitrary, like the dyes in fluorescence microscopy. The processes are greatly sped up and show only the most important stages.

Did you know…?

  • An adult human body is made of about 30–37 trillion cells (estimates vary). By count, most of them are red blood cells — though they are so small that they weigh very little.
  • Mitochondria have their own DNA (in humans a circular molecule of 16,569 base pairs) and divide like bacteria. It is a trace of an ancient symbiosis: according to endosymbiotic theory, their ancestors were bacteria that came to live inside another cell.
  • The DNA from the nucleus of a single one of your cells is about 2 m long when stretched out, yet it fits into a nucleus about 6 µm across.

Challenges

  • Score 10 points in the quizTurn on the quiz (Q) and hit the named organelles.
  • Follow a protein from DNA to the outside of the cellProcesses mode → From gene to protein, every step up to exocytosis.
  • Pause mitosis in metaphasePress pause when the chromosomes line up along the cell's equator.
  • Discover 12 different organellesSelect them with a click, a tap or the keyboard.
Dig deeper: the DNA helix
How the molecule that the nucleus copies genes from is built.